Based on a comparison of patients with normal and elevated IMTs, in some cases, it was possible to determine a plausible type of CKD–CVD relationship, i.e., independent (effects of CKD and CVD are additive): MPO, ALP, MMP-9, and MMP-9/TIMP-1; combined (CKD and CVD, acting together, have an enhanced effect on a marker due to their interaction): AOPPs and TIMP-1; conditional (the CVD effect is specific only to CKD patients): AGEs, 3-NT, magnesium, UIBC, TIBC, ALT, and TIMP-1/MMP-9. This evidence concerns the gene MPO and chronic kidney disease.