VEGF is the most potent activator of angiogenesis, stimulating the migration and proliferation of endothelial cells to generate and stabilize new blood vessels, leading to bronchial cell remodeling and inflammation, which in turn contribute to the onset and progression of various pulmonary diseases including PAH, COPD, bronchial asthma, and ILD [10]. The gene discussed is VEGFA; the disease is chronic obstructive pulmonary disease.