DNM1L and amyotrophic lateral sclerosis: Similarly, in the ALS mouse model, levels of the fusion proteins MFN1 and OPA1 as well as the cleavage proteins DRP1 and FIS1 were elevated by 10 weeks compared to wild mice, but levels of the fusion proteins were reduced from 10 to 18 weeks, whereas the cleavage proteins remained at high levels [119].