PRKN and Parkinson disease: Chen et al. mimicked the PD phenotype by using mice with the mutant α-syn A53T gene in dopaminergic neurons and found that mutant α-syn targets mitochondria, leading to mitophagy damage and subsequent apoptosis in dopaminergic neurons, and that deletion of the PINK1 and Parkin genes also leads to impaired mitophagy [67].