Calcium dysregulation is present in patients with genetic PD, and knockout or mutation of the PINK1 gene leads to mitochondrial calcium deposition, induces mitochondrial calcium overload, increases ROS production, enhances mitochondrial fission, and further exacerbates Ca2+ disorders, which ultimately leads to shifts in mitochondrial enzyme permeability and neuronal cell death [91,92]. The gene discussed is PINK1; the disease is Parkinson disease.