PINK1 and Parkinson disease: In addition, the transfection of SH-SY5Y cells with PINK1 siRNA to silence PINK1 in the SH-SY5Y cell line revealed decreased mtDNA levels and mtDNA synthesis, impaired oxidative phosphorylation, triggered an increase in Cyt-c release from mitochondria, increased oxidative stress, and inhibited normal cellular respiration, which ultimately induced cell death typical of the pathophysiology of PD [93].