We hypothesized that 9-HODE and 9-HOTrE would contribute to fasting-mediated hepatic steatosis and alter the expression of genes involved in lipid metabolism, uptake, and synthesis in a manner similar to hCYP2B6-Tg mice in comparison to Cyp2b-null mice using RNAseq. The gene discussed is CYP2B6; the disease is fatty liver disease.