MAPT and Alzheimer disease: Various factors have been identified as risk factors for AD, including a low score on the Mini-Mental State Examination (MMSE), a high score on the Alzheimer’s Disease Assessment Scale-cognitive subscale (ADAS-cog), positive APOE4 status, white matter hyperintensity volume, entorhinal cortex atrophy, cerebrospinal fluid (CSF) total tau levels, CSF neurogranin levels, dependency on instrumental activities of daily living (IADL), and being female [7,8,9].