Given the importance of fibrosis as a prognostic indicator in MASH, we used miRWalk to screen for EV miRs that target fibrosis-related genes such as collagens, ACTA2, MMPs, and TIMPs based on the predicted presence of miR-binding sites in the 3′-UTR or 5′-UTR, which, upon binding by the specific miR, results in post-transcriptional cleavage or repression of the respective target gene. The gene discussed is ACTA2; the disease is metabolic dysfunction-associated steatohepatitis.