In the quantitative analysis for the SGLT2 and GLUT2 expression in the mouse renal tissue, the mRNA production amounts of both SGLT2 and GLUT2 were higher in the STZ-administered mice than in healthy mice, and in healthy mice with malocclusion and in the STZ-administered mice it was higher with malocclusion than without malocclusion (Figure 5). The gene discussed is SLC2A2; the disease is Dental malocclusion.