Therefore, it is thought that inflammatory cytokines are produced due to the chronic inflammation by intestinal bacteria in the intestines, which are fatigued due to indigestion caused by malocclusion, and enter the kidneys via the circulation and promote the activation of the common transcription factor Hnf1α, which is responsible for SGLT2/GLUT2 expression in the renal tubules. This evidence concerns the gene HNF1A and Dental malocclusion.