Since susceptibility to blood glucose increases under diabetic conditions and the expressions of SGLT2 and GLUT2 are increased in patients with diabetes with persistent hyperglycemia, malocclusion may be one of the most serious exacerbating factors for not only diabetes but also diabetic nephropathy in patients with reduced occlusal support conditions associated with increased poor glycemic control in patients with diabetes. Here, SLC5A2 is linked to diabetes mellitus.