Furthermore, for each copy of the minor allele of the MUC5B promoter polymorphism, there was a 0.64% absolute increase in the percentage of the lung with interstitial changes [30], the MUC5B genotype was strongly associated with the subpleural subtype of ILA and was predictive of a UIP pattern in non-Hispanic white populations [31]. Here, MUC5B is linked to idiopathic pulmonary fibrosis.