Early myoclonic encephalopathy associated with metabolic disorders, genetic variants in STXBP1, TBC1D24, and GABRA1, and epilepsy of infancy with migrating focal seizures are related to pathogenic variants of KCNT1, SCN2A, SCN1A, SLC25A22, PLCB1, and QARS genes. Here, STXBP1 is linked to Other metabolic disease.