Some genetic factors are associated with an increased risk of PDA, such as TFAP2B (rs987237), TRAF1 (rs1056567), and AGTR1 (rs5186), while others, such as PTGIS (rs493694, rs693649), ESR1 (rs2234693), and IFN-g (rs2430561), are linked to decreasing the risk of PDA. The gene discussed is TRAF1; the disease is Patent ductus arteriosus.