Previous studies have attempted to investigate the correlation between clinical factors and the upstaging of cT1 RCC to pT3a, including age, RENAL score, and laboratory indices such as the serum aspartate aminotransferase (AST) to alanine aminotransferase (ALT) ratio (AST/ALT ratio) [13,15,16,17]. The gene discussed is GPT; the disease is renal cell carcinoma.