Glioblastoma IDH-wildtype (G4IDHwt) is defined as a diffuse infiltrative glial astrocytic proliferation without an IDH gene mutation that associates one or more of the following characteristics: tumor necrosis, microvascular proliferation, TERT promoter mutation, EGFR gene amplification, and/or numerical alteration of chromosomes +7/−10 [5]. The gene discussed is IDH2; the disease is glioblastoma.