A major player in the initiation of this inflammatory cascade is the nucleotide-binding domain, leucine-rich repeat (NLR) family pyrin domain containing 3 (in short, NLRP3) macromolecule, a well-understood inflammasome that persuades the maturation and secretion of pro-inflammatory cytokines such as interleukin-1β (IL-1β) and IL-18, with aberrant activation of this inflammasome complex proving to be implicated in the development of neurodegenerative and age-related CNS diseases like PD [42,43,49]. This evidence concerns the gene NLRP3 and Parkinson disease.