In addition to this, many of the genes that are associated with monogenic cases of PD (e.g., PARK 2/Parkin, PINK-1, DJ-1, and LRRKS) encode for proteins that regulate mitochondrial function and ROS homeostasis and, when mutated, induce symptoms that bare a strong resemblance to the motor/postural abnormalities seen in PD (e.g., dystonic gait, leg tremor, L-Dopa responsive dystonia, freezing, etc.)[4,50]. This evidence concerns the gene PRKN and Parkinson disease.