Heme oxygenase-1 (HO-1), normal human bronchial epithelial cells (NHBEs), immortalized human bronchial epithelial cells (HBECs), lung adenocarcinoma cells (A549), pancreatic cancer (PANC-1 cells), silent mating-type information regulation 2 homolog 3 (Sirt3), Toll-like receptor 4 (TLR4), multidrug resistance protein 1 (MRP1). The gene discussed is HMOX1; the disease is pancreatic neoplasm.