Soman potently inhibited signal transducer and activator of transcription (STAT) phosphorylation, resulting in the decreased expression of glycolytic enzymes (hexokinase 2 [HK2], pyruvate kinase M2 [PKM2], and lactate dehydrogenase A [LDHA]) and activities of pyruvate kinase (PK) and lactate dehydrogenase (LDH), leading to suppressed aerobic glycolysis and proliferation in cancer cells. This evidence concerns the gene HK2 and cancer.