For instance, mutations in the nuclear gene G elongation factor mitochondrial 1 (GFM1), which encodes the mitochondrial translation elongation factor G1 (EF-G1), cause combined oxidative phosphorylation deficiency type 1, an autosomal recessive disorder which manifests as dystonia, feeding difficulties, and severe encephalopathy, among other symptoms [23]. This evidence concerns the gene GFM1 and Encephalopathy.