The presence of the HO-1 L allele of the (GT)n locus has been associated with the occurrence of malignant mesothelioma and lung carcinoma in Japanese subjects, whereas the S allele has been associated with either malignant melanoma in Austrian individuals or gastric cancer in Iranian patients and Japanese women [186,187,188,189,190]. The gene discussed is HMOX1; the disease is lung carcinoma.