This controversy was solved in a meta-analysis of 5 studies (1751 T2DM patients and 2902 controls, including 190 and 235 Caucasians, respectively) by Bao et al. who confirmed that subjects harboring the HO-1 L allele of the (GT)n locus, in particular with the LL genotype, have an increased risk of T2DM [176]. The gene discussed is HMOX1; the disease is type 2 diabetes mellitus.