HMOX1 and cancer: With the purpose to clarify the role of HO-1 genetic variants in cancer, Wang et al. meta-analyzed 14 studies (2471 cancer patients and 2654 controls) and found that patients from East Asia carrying the HO-1 L allele of the (GT)n locus (LL and LL + LS genotypes) had higher susceptibility of developing cancer, in particular digestive tract cancers, than those with the S allele (SS and SS + SL genotypes) [35].