In an attempt to solve this conundrum, Zhang et al. meta-analyzed 23 studies involving 12,130 patients with CHD or RS and 14,181 controls and confirmed that Asian subjects carrying the SS genotype of the HO-1 (GT)n locus have a lower risk of developing CHD than those with the SL + LL and LL genotypes [36]. This evidence concerns the gene HMOX1 and coronary artery disorder.