Blimp-1 is a transcriptional repressor that is able to modulate these programs; given that chronic diseases like type 2 diabetes, cardiovascular disease, and autoimmune disorders are often driven by chronic inflammatory and oxidative stress, the ability to regulate Blimp-1’s activity would improve the body’s ability to offset these processes [5,6,8,9,10,20,21,140,141]. Here, PRDM1 is linked to autoimmune disease.