Endothelial dysfunction is also closely related to CKD and endothelial cell senescence is also characterized by increased resistance to apoptosis, increased release of ROS release and increased expression of adhesion molecules on endothelial cells, such as CD31 (PECAM-1), as well as the production of thrombotic factors, such as tissue factor (TF or CD142), which promotes fibrin formation by regulating the extrinsic coagulation system, allowing clot stabilization in the presence of platelets [11]. Here, F3 is linked to endothelial dysfunction.