The genetic variants significantly associated with obesity and low energy intake included SEC16 homolog B, endoplasmic reticulum export factor (SEC16B rs506589), brain-derived neurotrophic factor (BDNF rs6265), FTO (rs1421085), gastric inhibitory polypeptide receptor (GIPR rs1444988703), and BDNF Antisense RNA (BDNF-AS rs925947) (p < 5 × 10−8). The gene discussed is SEC16B; the disease is Obesity.