C1P is involved in several pathways, such as the mammalian target of rapamycin (mTOR), phosphatidylinositol 3-kinase (PI3K)/Akt, nuclear factor kappa light chain enhancer of activated B cells (NF-κB), protein kinase C-α, c-Jun N-terminal kinase (JNK), vascular endothelial cell growth factor (VEGF), and mitogen-activated protein kinase kinase (MEK)/extracellularly regulated kinases (ERKs) 1/2 [25,56], all described in studies involving migraine. This evidence concerns the gene MAPK8 and migraine disorder.