The aSMase levels were significantly elevated in both EM (3.62 ± 1.25 ng/mL,) and CM (3.07 ± 0.95 ng/mL,) patients with migraine compared to the controls (1.58 ± 0.72 ng/mL) (p < 0.0001); meanwhile, no differences were found between EM and CM (p = 0.1159) (Figure 1; Table 1). Here, SMPD1 is linked to migraine disorder.