It should be noted that aSMase activity can be increased by the action of pro-inflammatory stimuli, such as Tumor Necrosis Factor α (TNF-α), Interleukin-1β (IL-1β) or cytosolic phospholipase A2 (cPLA2), also involved in migraine [4,5,50,75,76,77]. This evidence concerns the gene TNF and migraine disorder.