The JNK/ERK/MAPK pathway induces the expression of dosage-sensitive sex-reversal–adrenal hypoplasia congenita critical region on the X chromosome, gene 1 (DAX-1), which represses several transcription factors involved in steroidogenesis, in particular the orphan nuclear receptors nuclear receptor subfamily 4 group A member 1 (Nur77) and steroidogenic factor 1 (SF-1) [85,87,88]. Here, NR4A1 is linked to alternating hemiplegia of childhood.