Since one of mechanisms underlying chemotherapy-induced neuropathy involves oxidative stress and the induction of antioxidant enzymes, such as HO-1, which can attenuate the mechanical and thermal allodynia caused by PTX [22], the activation of the endogenous antioxidant system by MCC950 suggests that this system could contribute to the antiallodynic effects of this NLRP3 inhibitor. This evidence concerns the gene HMOX1 and neuropathy.