In the lysosomal storage disorder, Niemann Pick type-C (NPC), for example, loss of function of lysosomal lipid transport proteins NPC1 or NPC2 causes the accumulation of lysosomal lipids, but, intriguingly, additionally results in mitochondrial dysfunction [3], indicating functional crosstalk between the two organelles. This evidence concerns the gene NPC1 and nasopharyngeal carcinoma.