Given that the PINK1/parkin-mediated MDV formation and targeting to the lysosome for degradation is diminished in models of PD, and that neuroinflammation and increased IL-6 levels have been identified in PD patient tissue [195], it is possible that MDVs containing increased levels of oxidized IMM/matrix proteins may be secreted and play a role in the increased inflammatory phenotype and, therefore, the pathogenesis of PD. This evidence concerns the gene PINK1 and Parkinson disease.