NFE2L2 and neurodegenerative disease: Sulforaphane, an isothiocyanate produced when cruciferous vegetables are chewed, is another compound that prevents oxidative stress-induced cytotoxicity through the increase in the Nrf2 expression and decreasing HO-1 and NQO-1 targets in neuro2a cells and the sciatic nerve of diabetic animals, thus demonstrating its protective potential in neurodegenerative diseases [124].