NFE2L2 and neurodegenerative disease: Continuing other plant-derived compounds, ellagic acid is a bioactive polyphenolic compound naturally occurring as secondary metabolite in many plant taxa that can inhibit the Keap1 to accumulate the Nrf2 in the nucleus and act on the ARE to produce target proteins, which in turn may alleviate the effects of ROS on neuronal cells in neurodegenerative diseases [126].