GNAS and neoplasm: These multiple observations supporting a possible association of GNAS mutation with a favorable prognosis in iIPMN may be explained, in part, by the association of GNAS mutation with decreased tumor invasion—as seen in our study, as well as in the studies of Gaujoux et al. and Ideno et al., which showed invasive IPMNs to be enriched with wild-type GNAS and only 11–25% of invasive IPMNs to have GNAS mutant status [17,28].