Furthermore, the growth of H460 lung tumour xenografts expressing KIF15-targeted shRNA was significantly impaired in mice, and stunted tumour growth was associated with the downregulation of components of the Raf-Mek-ERK signalling pathway, including phospho-ERK, ATF2, phospho-MEK, and phospho-c-Raf [156]. This evidence concerns the gene MAP2K7 and neoplasm.