Overall, HPV+ HNC displays several features associated with a more inflammatory or “hotter” TME, such as increased B cell infiltrates and higher frequencies of PD-1+ CD8+ tumor-infiltrating lymphocytes (TIL), type 1 helper (TH1) CD4+ T cells, TH17 CD4+ T cells, and follicular helper (TFH) CD4+ T cells [24]. This evidence concerns the gene CD4 and neoplasm.