In a systematic search of scientific literature for germline mutations, familial predispositions, and clinical implications in PCa, from 2000 to 2022, germline mutations in HR genes (BRCA1/2, ATM, and CHECK2), in MMR genes (MLH1, MLH2, and MSH6), and other additional genes were found to be involved in the pathogenesis of PCa and progression to metastasis [35]. This evidence concerns the gene HR and posterior cortical atrophy.