The WGS of advanced PCa cases (45 progressed tumors vs. 11 unmatched non-tumors) in patients of African ancestry showed that in comparison with TCGA-based data for EA men, AA men had higher levels of mutations in the BRCA2 (27%), APC (20%), ATM (20%), BRCA1 (13%), DNAJC6 (13%), EGFR (13%), MAD1L1 (13%), MLH1 (11%), and PMS2 (11%) genes [46]. This evidence concerns the gene PMS2 and posterior cortical atrophy.