The NCCN Guidelines for PCa recommend germline multigene testing that includes at least BRCA1, BRCA2, ATM, PALB2, CHEK2, HOXB13, MLH1, MSH2, MSH6, and PMS2, which are genes involved in both the HR and MMR DNA damage repair pathways. This evidence concerns the gene BRCA2 and posterior cortical atrophy.