CHEK2 and posterior cortical atrophy: In a meta-analysis of largely EA patients, who were diagnosed with advanced PCa progressing to metastatic or PCa-related death, mutation rates in the NBN, BRCA2, ATM, CHEK2, and PALB2 (p < 0.05) genes, with corresponding ORs of 6.38, 3.41, 1.93, 1.53, and 2.63, were notably higher than in nonaggressive PCa patients [43].