The comparison of whole exome sequencing of AA PCa patient cohorts (n = 960 and n = 747) and 8128 control cases of AA men from the Genome Aggregation Database for germline mutations, showed that two variants, R14Q in GPRC5C and R511Q in IGF1R, even at low incidence, 0.47–0.53% vs. 0.01% in the control population, had ORs for PCa of 37.46 and 21.54, respectively, underscoring the need for genetic testing in underrepresented populations [65]. Here, GPRC5C is linked to posterior cortical atrophy.