In a study investigating the scope of DDR gene germline mutations in 3607 PCa patients from diverse populations, it was found that 17.2% had a positive P/LP variant as follows: BRCA2, 4.74%; CHEK2, 2.88%; ATM, 2.03%; MUTYH, 2.37%; APC, 1.28%; BRCA1, 1.25%; and PALB2, 0.56%. The gene discussed is APC; the disease is posterior cortical atrophy.