From TCGA and the GEO database, we proved that high expression of KPNA2, FOXM1, CCNB1, and CCNB2 were correlated with poor survival of BC patients, especially elevated levels of both KPNA2 and FOXM1 mRNA were significantly associated with poorer OS (Figure 4a, p = 0.0046) and DSS (Figure 4b, p = 0.006). This evidence concerns the gene KPNA2 and breast cancer.