On the other hand, hormonally active tumors gave symptoms dependent on secreted hormones, i.e., lactotroph—mainly menstrual disorders in women; corticotroph—symptoms resulting from hypercorticism; somatotroph—symptoms of acromegaly; mature Pit-1-lineage tumor—mainly symptoms of excess PRL and GH. The gene discussed is GH1; the disease is adrenal gland hyperfunction.