Rearrangements involving MYB or MYBL1 are highly specific for ACC and constitute valuable diagnostic hallmarks, usually identified with FISH or NGS, not only for salivary gland ACC but also for ACC arising in other anatomic sites (lung, breast, trachea, sinonasal cavity, lacrimal glands, and skin) [40,41,42]. The gene discussed is MYB; the disease is adrenal cortex carcinoma.