Tetzlaff et al. [19] performed whole exome next-generation sequencing on 27 sebaceous carcinomas (23 periocular and 4 extraocular) from 20 patients. The most common genes with somatic mutations identified in the periocular tumors were TP53 (n = 9), RB1 (n = 6), PIK3CA (n = 2), PTEN (n = 2), ERBB2 (n = 2), and NF1 (n = 2). Here, RB1 is linked to sebaceous adenocarcinoma.