Thirty-six patients (28 females and eight males), aged between 14 and 67 years, with clinical, laboratory, radiological, and histopathological diagnoses of ACTH-dependent hypercortisolism (Cushing’s disease (n = 29) or ectopic ACTH-syndrome (n = 7)) were included in this study. This evidence concerns the gene POMC and ACTH Syndrome, Ectopic.