Other genes, such IRX4, are known to be silenced epigenetically and under-expressed in pancreatic cancer [46] or AMER2 (also called FAM123A), which is known to be a negative regulator of WNT signaling and its aberrant methylation and to be correlated to progression in precancerous stages in gastric carcinomas [44]. Here, IRX4 is linked to familial pancreatic carcinoma.