Subtyping analysis and comparison of ECs between MM stages using scRNA-seq revealed a pre-vascular to angiogenic shift in ECs from MGUS to MM, an increase in IFN signaling in subsets of ECs in MM that may represent a unique MM subtype, and transcriptional changes associated with angiogenesis, migration, lipid metabolism, and increased expression of SOX18 during MM progression [17]. The gene discussed is SOX18; the disease is Miyoshi myopathy.