CD274 and neoplasm: Indeed, the relevance of tumor histology was discrepant across studies important, as PEARLS subgroup analyses showed no benefit in patients with squamous NSCLC (HR 1.04; 95% CI, 0.75–1.45), differently than in IMpower010 (HR 0.80; 95% CI, 0.54–1.18); similarly the influence of a tumor’s PD-L1 expression, even if the discrepancy between the trial outcomes was a function of PD-L1 status, remains largely unexplained [26].