CTNNB1 and posterior cortical atrophy: Interestingly, co-occurrence of the TPMRSS2-ERG fusion and a gain-of-function TP53 mutant was shown to accelerate PCa growth in vitro and in mice by activating beta-catenin expression and promoting pyrimidine synthesis, indicating that different TP53 mutations or deletions may have distinct effects during PCa progression [23].