Early whole-exome and -transcriptome sequencing studies in mCRPC patients have shown that somatic TP53 mutations are the most selectively mutated genes in mCRPC compared to primary PCa samples and, besides alterations in AR, the most frequent alteration found (in up to 50% of mCRPC samples) [7,69] (Figure 3). The gene discussed is TP53; the disease is posterior cortical atrophy.