TP53 and cancer: Regarding macrophages, p53-null cancer cells have been reported to resist macrophage-mediated phagocytosis by producing extracellular vesicles enriched with immunosuppressive PD-L1 [30], and the tumor microenvironment (TME) shaped by p53-mutant cells fosters immune evasion through myeloid cell reprogramming and regulatory T cell (Treg) recruitment [32,33].