Regarding the relationship of miR-375-5p with MTC, different mechanisms have been proposed to explain its influence on MTC prognosis, including the downregulation of YAP1, which promotes tumor progression [4], and dysregulation of the phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway. The gene discussed is AKT1; the disease is medullary thyroid gland carcinoma.