Small molecules such as Heclin (a non-specific HECT E3 inhibitor) [177] and Indole-3-carbinol (I3C; inhibitor against NEDD4-1 and WWP1 catalytic HECT domains) [178,179] are capable of stabilizing PTEN, reducing Akt phosphorylation, and impairing cell viability in models of gastric cancer and melanoma [48]. This evidence concerns the gene PTEN and melanoma.