WWP2 and central nervous system cancer: Similarly, the WWP2 (WW domain-containing E3 ubiquitin protein ligase 2)-PTEN axis [191] has been implicated in prostate, endometrial, hepatocellular, oral squamous cell cancers, and glioma [46,192,193,194,195], where WWP2 overexpression correlates with aggressive tumor phenotypes and poor prognosis.