In addition to IER5, IER5L and IER2—two homologues of IER5 with structural similarity [18]—are also highly expressed and promote tumor progression, metastasis, and invasion in various cancers including prostate cancer, non-small cell lung cancer, melanoma, and colorectal cancer [19,20,21,22]. The gene discussed is IER5; the disease is non-small cell lung carcinoma.