Sanger sequencing has identified mutations in WBP5 on the X chromosome in patients with colorectal cancer with microsatellite instability, implicating it as a potential mutational driver along with 14 other genes, including ADAR, DCAF12L2, GLT1D1, ITGA7, MAP1B, MRGPRX4, PSRC1, RANBP2, RPS6KL1, SNCAIP, TCEAL6, TUB6, VEGFB, and ZBTB2 [4,5]. The gene discussed is TCEAL9; the disease is colorectal cancer.