For example, the TRM6/TRM61A complex catalyzes m1A methylation at position 58 of the T-loop in initiator methionine tRNAs, stabilizing its structure [24], and dysregulation of the TRM6/TRM61A complex has been implicated in various tumors, including gliomas, by altering translation patterns [25,26]. This evidence concerns the gene TRMT6 and central nervous system cancer.