CTNNB1 and neoplasm: For instance, a study by Wu and colleagues describes how the m5C and 5-hydroxymethylcytosine (hm5C) writers, NSUN5 and TET2, respectively, mediate the methylation of the chromatin-associated RNA CTNNB1 at the fifth cytosine position, followed by its oxidation to hm5C, promoting CTNNB1 degradation through RBFOX2 and subsequent phagocytosis by tumor-associated macrophages (TAMs) [94].