A number of promising lncRNAs show altered expression in many tumor types, e.g., PCA3 (in prostate cancer), HOTAIR (breast cancer, laryngeal squamous cell carcinoma, cervical cancer, and urothelial bladder cancer), BCAR4 (colorectal cancer), and MALAT1 (non-small cell lung cancer) [203,204,205,206]. This evidence concerns the gene HOTAIR and Familial prostate cancer.