Other examples are HIF2PUT, which positively correlates with expression of the hypoxia-inducible factor-2α (HIF-2α) in osteosarcoma; paRNA_CDH1, which may promote the development of prostate cancer through the transcriptional inhibition of E-cadherin (CDH1); paRNA_VIM, which enhances vimentin transcription by achieving an open chromatin state through the formation of the R-loop, as observed in colon and breast cancers; and Khps1, which may promote the expression of the E2F1-mediated SPHK1 proto-oncogene in cervical cancer, liver cancer, and osteosarcoma [279,280,281,282]. The gene discussed is E2F1; the disease is osteosarcoma.