Tumor suppressor lncRNAs may activate the transcription of tumor suppressor genes (e.g., DIRC3—melanoma) by modifying local chromatin structure or reduce the proliferation and invasion of tumor cells (e.g., SATB2-AS1—colorectal cancer, LINC00261—lung cancer, PVT1—breast cancer, MEG3—colorectal cancer). The gene discussed is PVT1; the disease is neoplasm.