Some eRNAs are thought to be involved in cancer development and progression; for example, the estrogen-associated SMAD7e may contribute to carcinogenesis in the bladder, and reduction of its expression may initiate apoptosis and reduce tumor cell invasion [264], while TBX5-AS1 may affect the progression of non-small cell lung cancer through the regulation of the PI3K/AKT pathway [262,265]. This evidence concerns the gene AKT1 and neoplasm.