FH and hereditary disease: Harrison WJ et al. focused on the identification and characteristics of FH-deficient uterine leiomyomas, particularly in the context of HLRCC syndrome, and found that while most HLRCC patients have FH-deficient leiomyomas, 1% of all uterine leiomyomas also exhibit FH deficiency due to somatic mutations, making it difficult to use FH deficiency as a unique marker for hereditary disease.