From the histopathological point of view, these FH-deficient leiomyomas exhibit increased cellularity, nuclear atypia, and a higher mitotic index, contributing to their difficult management, considering their histological analogies with STUMP (smooth muscle tumor of uncertain malignant potential) and uLMS (uterine leiomyosarcoma) [2,4,5]. The gene discussed is FH; the disease is leiomyosarcoma.