Further study found that knocking down JAK3-INSL3 expression in CTCL cells led to decreased expression of total JAK3, pJAK3, pSTAT1, pSTAT3, pSTAT5, pSTAT6, and NFκb proteins, which resulted in reduced cell proliferation and decreased colony formation in MJ and HH cell lines, as well as smaller tumor sizes in NSG xenograft mice [14]. The gene discussed is JAK3; the disease is neoplasm.