MAPK8 and cancer: Analysis by qPCR using an independent set of PANC-1 cells validated the differential expression of genes associated with autophagy, like the GABA Type A Receptor Associated Protein Like 1 (GABARAP1L) and the Mitogen-Activated Protein Kinase 8 (MAPK8), necroptosis, like the Poly(ADP-Ribose) Polymerase 1 (PARP1), pathways in cancer, like CCND3, CDK6 and the CXC Motif Chemokine Ligand 2 (CXCL2) and Hippo signaling, like YAP1 (Figure 4G–J).