In addition, miR-21 expression was also increased with radiation dose in all three human esophageal squamous cell carcinoma cell lines (i.e., TE-1, EC1 and KYSE140) after γ-radiation at doses of 2, 4, 6 and 8 Gy in comparison to unirradiated cell; and miR-21 that targets MSH2 and MSH6 mRNA has been found to be overexpressed in MSI-high CRC [50]. The gene discussed is MSH2; the disease is colorectal carcinoma.