Overexpression of miR-155 has been reported to significantly down-regulate the core MMR proteins (MSH2, MSH6 and MLH1) and to induce a mutator phenotype and MSI; and an inverse correlation between the expression of miR-155 and the expression of MLH1 or MSH2 proteins was found in human CRC [49]. Here, MSH6 is linked to colorectal carcinoma.