Together with the over expression of mouse double minute 2 (MDM2), it has a role in BC via the augmentation of BC invasion and migration through negatively regulating P53 as well as tumor necrosis factor α (TNFα), which elicits inhibition of cell proliferation, induction of apoptosis, and even the enhancement of cell migration, as well as contributing to poor prognosis outcomes. This evidence concerns the gene TP53 and breast cancer.