In animals receiving the grape diet, there were also 20 top pathways listed in which SDGF was enriched relative to SDGM (Figure 7B), five of which were the same as with the non-grape-fed groups (PPAR signaling, primary immunodeficiency, cholesterol metabolism, S. aureus infection, and complement and coagulation cascades). This evidence concerns the gene AREG and inborn error of immunity.