PFKFB3 and asthma: In addition, miR396, derived from the astragalus root, regulates GATA-3 expression, and suppressed STAT-6 and ROR-γt mRNA in an asthma model of mice [54], and the miR396 presence in garlic exosomes indicates that miR-396e, one of the most prevalent miRNAs of GDE, played a crucial role in promoting the metabolic reprogramming of macrophage through PFKFB3 [55].